Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds

doi:10.1093/molbev/msae108

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	Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds
	Wang, Shi-Zhi 1,2; Yan, Yu 3; Widlund, Malin 4; Qian, Chen-Chang 1,5; Zhang, Liang-Liang 6; Zhang, Shao-Jie 1,5; Li, Zi-Mai 7; Cao, Peng 8; Dai, Qing-Yan 8; Feng, Xiao-Tian 8; Liu, Feng 8; Wang, Lu 3; Gao, Chao 7; Fu, Qiao-Mei8 ; Hytonen, Marjo K.9,10; Lohi, Hannes 9,10; Savolainen, Peter 4; Wang, Guo-Dong 1,5
	2024-07-05
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	41 期号:7 页码:12
通讯作者	Savolainen, Peter([email protected]) ; Wang, Guo-Dong([email protected])
摘要	The origins and extreme morphological evolution of the modern dog breeds are poorly studied because the founder populations are extinct. Here, we analyse eight 100 to 200 years old dog fur samples obtained from traditional North Swedish clothing, to explore the origin and artificial selection of the modern Nordic Lapphund and Elkhound dog breeds. Population genomic analysis confirmed the Lapphund and Elkhound breeds to originate from the local dog population, and showed a distinct decrease in genetic diversity in agreement with intense breeding. We identified eleven genes under positive selection during the breed development. In particular, the MSRB3 gene, associated with breed-related ear morphology, was selected in all Lapphund and Elkhound breeds, and functional assays showed that a SNP mutation in the 3 ' UTR region suppresses its expression through miRNA regulation. Our findings demonstrate analysis of near-modern dog artifacts as an effective tool for interpreting the origin and artificial selection of the modern dog breeds.
关键词	historic dog fur lapphund elkhound genetic origin artificial selection population genomics
DOI	10.1093/molbev/msae108
关键词[WOS]	GENOME SEQUENCE ; VILLAGE DOGS ; DIVERSITY ; SUGGESTS ; REVEALS ; TOOL
收录类别	SCI
语种	英语
资助项目	NSFC[32170436] ; NSFC[32360122] ; National Key R&D Program of China[2019YFA0707101] ; Agria och SKK Forskningsfond for sallskapsdjur[N2021-0019] ; Agria och SKK Forskningsfond for sallskapsdjur[2021ZD0203900] ; Spring City Plan: the High-level Talent Promotion and Training Project of Kunming[2022SCP001] ; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences[GREKF21-10] ; Yunnan Fundamental Research Projects[202201AV070011] ; Aatos Erkko Foundation ; HiLIFE
项目资助者	NSFC ; National Key R&D Program of China ; Agria och SKK Forskningsfond for sallskapsdjur ; Spring City Plan: the High-level Talent Promotion and Training Project of Kunming ; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences ; Yunnan Fundamental Research Projects ; Aatos Erkko Foundation ; HiLIFE
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号	WOS:001262905200002
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/23817
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Savolainen, Peter; Wang, Guo-Dong
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Genet Evolut & Anim Models, Yunnan Key Lab Mol Biol Domest Anim, Kunming, Peoples R China 2.Yunnan Anim Sci & Vet Inst, Kunming, Peoples R China 3.Yunnan Univ, State Key Lab Conservat & Utilizat Bioresources Yu, Kunming, Peoples R China 4.KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden 5.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Peoples R China 6.Zhejiang Normal Univ, Xingzhi Coll, Jinhua, Peoples R China 7.Shandong Univ, State Key Lab Microbial Technol, Qingdao, Peoples R China 8.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China 9.Univ Helsinki, Dept Med & Clin Genet, Dept Vet Biosci, Helsinki, Finland 10.Folkhalsan Res Ctr, Helsinki, Finland
推荐引用方式 GB/T 7714	Wang, Shi-Zhi,Yan, Yu,Widlund, Malin,et al. Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds[J]. MOLECULAR BIOLOGY AND EVOLUTION,2024,41(7):12.
APA	Wang, Shi-Zhi.,Yan, Yu.,Widlund, Malin.,Qian, Chen-Chang.,Zhang, Liang-Liang.,...&Wang, Guo-Dong.(2024).Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds.MOLECULAR BIOLOGY AND EVOLUTION,41(7),12.
MLA	Wang, Shi-Zhi,et al."Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds".MOLECULAR BIOLOGY AND EVOLUTION 41.7(2024):12.