Dinosaur's feather and chicken's tooth? Tissue engineering of the integument

IVPP-IR > 中科院古脊椎所（2000年以后）

	Dinosaur's feather and chicken's tooth? Tissue engineering of the integument
	Chuong, CM ; Hou, LH ; Chen, PJ ; Wu, P ; Patel, N ; Chen, YP ; Chuong, CM (reprint author), Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA.
	2001-07-01
发表期刊	EUROPEAN JOURNAL OF DERMATOLOGY
ISSN	1167-1122
卷号	11 期号:4 页码:286-292
文章类型	Review
摘要	The integument forms the interface between animals and the environment. During evolution, diverse integument and integument appendages have evolved to adapt animals to different niches. The formation of these different integument forms is based on the acquisition of novel developmental mechanisms. This is the way Nature does her tissue/organ engineering and experiments. To do tissue engineering of the integument in the new century for medical applications, we need to learn more principles from developmental and evolutionary studies. A novel diagram showing the evolution and development of integument complexity is presented, and the molecular pathways involved discussed. We then discuss two examples in which the gain and loss of appendages are modulated: transformation of avian scale epidermis into feathers with mutated beta catenin, and induction of chicken tooth like appendages with FGF, BMP and feather mesenchyme.; The integument forms the interface between animals and the environment. During evolution, diverse integument and integument appendages have evolved to adapt animals to different niches. The formation of these different integument forms is based on the acquisition of novel developmental mechanisms. This is the way Nature does her tissue/organ engineering and experiments. To do tissue engineering of the integument in the new century for medical applications, we need to learn more principles from developmental and evolutionary studies. A novel diagram showing the evolution and development of integument complexity is presented, and the molecular pathways involved discussed. We then discuss two examples in which the gain and loss of appendages are modulated: transformation of avian scale epidermis into feathers with mutated beta catenin, and induction of chicken tooth like appendages with FGF, BMP and feather mesenchyme.
关键词	Dinosaur Evolution Feather Hair Stent Cells Teeth Tissue Engineer
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	NORTHEASTERN CHINA ; DERMAL PAPILLA ; BETA-CATENIN ; MORPHOGENESIS ; SKIN ; APPENDAGES ; EPITHELIUM ; EVOLUTION ; INDUCTION ; SCALES
收录类别	SCI
语种	英语
WOS研究方向	Dermatology
WOS类目	Dermatology
WOS记录号	WOS:000169744300002
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/3859
专题	中科院古脊椎所（2000年以后）
通讯作者	Chuong, CM (reprint author), Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA.
作者单位	1.Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA 2.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Geol & Paleontol, Nanjing, Peoples R China 4.Tulane Univ, Dept Cell & Mol Biol, New Orleans, LA 70118 USA
推荐引用方式 GB/T 7714	Chuong, CM,Hou, LH,Chen, PJ,et al. Dinosaur's feather and chicken's tooth? Tissue engineering of the integument[J]. EUROPEAN JOURNAL OF DERMATOLOGY,2001,11(4):286-292.
APA	Chuong, CM.,Hou, LH.,Chen, PJ.,Wu, P.,Patel, N.,...&Chuong, CM .(2001).Dinosaur's feather and chicken's tooth? Tissue engineering of the integument.EUROPEAN JOURNAL OF DERMATOLOGY,11(4),286-292.
MLA	Chuong, CM,et al."Dinosaur's feather and chicken's tooth? Tissue engineering of the integument".EUROPEAN JOURNAL OF DERMATOLOGY 11.4(2001):286-292.