KMS Institute of Vertebrate Paleontology and Paleoanthropology
| African lungfish genome sheds light on the vertebrate water-to-land transition | |
Wang, Kun1; Wang, Jun2,3; Zhu, Chenglong1,4; Yang, Liandong5; Ren, Yandong1,4; Ruan, Jue6; Fan, Guangyi7,8; Hu, Jiang9; Xu, Wenjie1; Bi, Xupeng8; Zhu, Youan10; Song, Yue7; Chen, Huatao11; Ma, Tiantian11; Zhao, Ruoping4; Jiang, Haifeng5; Zhang, Bin12,13; Feng, Chenguang1; Yuan, Yuan1; Gan, Xiaoni5; Li, Yongxin1; Zeng, Honghui5; Liu, Qun7; Zhang, Yaolei7; Shao, Feng14; Hao, Shijie7; Zhang, He7; Xu, Xun8; Liu, Xin7; Wang, Depeng9; Zhu, Min10 ; Zhang, Guojie4,8,15,16; Zhao, Wenming12,13; Qiu, Qiang1; He, Shunping5,15,17; Wang, Wen4,15,18
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| 2021-03-04 | |
| 发表期刊 | CELL
 |
| ISSN | 0092-8674 |
| 卷号 | 184期号:5页码:1-15 |
| 摘要 | Lungfishes are the closest extant relatives of tetrapods and preserve ancestral traits linked with the water-to-land transition. However, their huge genome sizes have hindered understanding of this key transition in evolution. Here, we report a 40-Gb chromosome-level assembly of the African lungfish (Protopterus annectens) genome, which is the largest genome assembly ever reported and has a contig and chromosome N50 of 1.60 Mb and 2.81 Gb, respectively. The large size of the lungfish genome is due mainly to retrotransposons. Genes with ultra-long length show similar expression levels to other genes, indicating that lungfishes have evolved high transcription efficacy to keep gene expression balanced. Together with transcriptomeand experimental data, we identified potential genes and regulatory elements related to such terrestrial adaptation traits as pulmonary surfactant, anxiolytic ability, pentadactyl limbs, and pharyngeal remodeling. Our results provide insights and key resources for understanding the evolutionary pathway leading from fishes to humans. |
| DOI | 10.1016/j.cell.2021.01.047 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Fish10K project ; Strategic Priority Research Program of CAS[XDB13000000] ; 1000 Talent Project of Shaanxi Province ; Research Funds for Interdisciplinary Subject, NWPU[19SH030408] ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Youth Innovation Promotion Association of the CAS ; NSFC of China[41876179] ; NSFC of China[31972866] ; Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2018) ; National Key Research and Development Program of China[2018YFD0900604] ; Villum Foundation[25900] ; Frasergen Bioinformatics Co., Ltd. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS记录号 | WOS:000629635700021 |
| 出版者 | CELL PRESS |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/18565 |
| 专题 | 中科院古脊椎所（2000年以后） |
| 通讯作者 | Zhao, Wenming; Qiu, Qiang; He, Shunping; Wang, Wen |
| 作者单位 | 1.Northwestern Polytech Univ, Sch Ecol & Environm, Xian 710072, Peoples R China 2.South China Agr Univ, Coll Marine Sci, Joint Lab Guangdong Prov & Hong Kong Reg Marine B, Guangzhou 510642, Peoples R China 3.Hubei Univ Technol, Sch Civil Engn Architecture & Environm, Wuhan 430068, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 6.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Genome Anal Lab,Minist Agr, Shenzhen 518120, Peoples R China 7.BGI Qingdao, Qingdao 266555, Peoples R China 8.BGI Shenzhen, Shenzhen 518083, Peoples R China 9.Grand Biosci, Beijing 102200, Peoples R China 10.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 11.Northwest A&F Univ, Coll Vet Med, Dept Clin Vet Med, Key Lab Anim Biotechnol,Minist Agr, Yangling 712100, Shaanxi, Peoples R China 12.Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China 13.China Natl Ctr Bioinformat, Beijing 100101, Peoples R China 14.Southwest Univ, Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev, Chongqing 400715, Peoples R China 15.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 16.Univ Copenhagen, Villum Ctr Biodivers Genom, Dept Biol, Sect Ecol & Evolut, Copenhagen, Denmark 17.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China 18.Northwestern Polytech Univ, Xian 710072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Kun,Wang, Jun,Zhu, Chenglong,et al. African lungfish genome sheds light on the vertebrate water-to-land transition[J]. CELL,2021,184(5):1-15. |
| APA | Wang, Kun.,Wang, Jun.,Zhu, Chenglong.,Yang, Liandong.,Ren, Yandong.,...&Wang, Wen.(2021).African lungfish genome sheds light on the vertebrate water-to-land transition.CELL,184(5),1-15. |
| MLA | Wang, Kun,et al."African lungfish genome sheds light on the vertebrate water-to-land transition".CELL 184.5(2021):1-15. |
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| zhu 2021 cell2.pdf（11704KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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