KMS Institute of Vertebrate Paleontology and Paleoanthropology
| Reconstructing the genetic history of late Neanderthals | |
| Hajdinjak, Mateja1; Fu, Qiaomei2,3,4; Huebner, Alexander1; Petr, Martin1; Mafessoni, Fabrizio1; Grote, Steffi1; Skoglund, Pontus5; Narasimham, Vagheesh5; Rougier, Helene6; Crevecoeur, Isabelle7; Semal, Patrick8; Soressi, Marie9,10; Talamo, Sahra10; Hublin, Jean-Jacques10; Gusic, Ivan11; Kucan, Zeljko11; Rudan, Pavao11; Golovanova, Liubov V.12; Doronichev, Vladimir B.12; Posth, Cosimo13,14; Krause, Johannes13,14; Korlevic, Petra1; Nagel, Sarah1; Nickel, Birgit1; Slatkin, Montgomery15; Patterson, Nick5,16; Reich, David5,16,17; Pruefer, Kay1; Meyer, Matthias1; Paeaebo, Svante1; Kelso, Janet1 | |
| 2018-03-29 | |
| 发表期刊 | NATURE
 |
| ISSN | 0028-0836 |
| 卷号 | 555期号:7698页码:652-+ |
| 文章类型 | Article |
| 摘要 | Although it has previously been shown that Neanderthals contributed DNA to modern humans(1,2), not much is known about the genetic diversity of Neanderthals or the relationship between late Neanderthal populations at the time at which their last interactions with early modern humans occurred and before they eventually disappeared. Our ability to retrieve DNA from a larger number of Neanderthal individuals has been limited by poor preservation of endogenous DNA(3) and contamination of Neanderthal skeletal remains by large amounts of microbial and present-day human DNA(3-5). Here we use hypochlorite treatment(6) of as little as 9 mg of bone or tooth powder to generate between 1- and 2.7-fold genomic coverage of five Neanderthals who lived around 39,000 to 47,000 years ago (that is, late Neanderthals), thereby doubling the number of Neanderthals for which genome sequences are available. Genetic similarity among late Neanderthals is well predicted by their geographical location, and comparison to the genome of an older Neanderthal from the Caucasus(2,7) indicates that a population turnover is likely to have occurred, either in the Caucasus or throughout Europe, towards the end of Neanderthal history. We find that the bulk of Neanderthal gene flow into early modern humans originated from one or more source populations that diverged from the Neanderthals that were studied here at least 70,000 years ago, but after they split from a previously sequenced Neanderthal from Siberia(2) around 150,000 years ago. Although four of the Neanderthals studied here post-date the putative arrival of early modern humans into Europe, we do not detect any recent gene flow from early modern humans in their ancestry. |
| WOS标题词 | Science & Technology |
| DOI | 10.1038/nature26151 |
| 关键词[WOS] | MITOCHONDRIAL GENOME SEQUENCE ; ANCIENT DNA ; DENISOVA CAVE ; MODERN HUMANS ; DAMAGED DNA ; SIBERIA ; POPULATIONS ; HOMININ ; CONTAMINATION ; EVOLUTIONARY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000428617600048 |
| 出版者 | NATURE PUBLISHING GROUP |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/8756 |
| 专题 | 中国科学院古脊椎动物与古人类研究所 |
| 通讯作者 | Hajdinjak, Mateja; Paeaebo, Svante; Kelso, Janet |
| 作者单位 | 1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins Chinese, IVPP, Beijing 100044, Peoples R China 3.CAS Ctr Excellence Life & Paleoenvironm, Beijing 100044, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA 6.Calif State Univ Northridge, Dept Anthropol, Northridge, CA 91330 USA 7.Univ Bordeaux, CNRS, UMR PACEA 5199, F-33615 Pessac, France 8.Royal Belgian Inst Nat Sci, B-1000 Brussels, Belgium 9.Leiden Univ, Fac Archaeol, NL-2300 RA Leiden, Netherlands 10.Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany 11.Croatian Acad Sci & Arts, HR-10000 Zagreb, Croatia 12.ANO Lab Prehist, 14 Linia 3 11, St Petersburg 199034, Russia 13.Max Planck Inst Sci Human Hist, D-07745 Jena, Germany 14.Univ Tubingen, Inst Archaeol Sci, Rumelin Str 23, D-72070 Tubingen, Germany 15.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 16.Broad Inst Harvard & MIT, Cambridge, MA 02142 USA 17.Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Hajdinjak, Mateja,Fu, Qiaomei,Huebner, Alexander,et al. Reconstructing the genetic history of late Neanderthals[J]. NATURE,2018,555(7698):652-+. |
| APA | Hajdinjak, Mateja.,Fu, Qiaomei.,Huebner, Alexander.,Petr, Martin.,Mafessoni, Fabrizio.,...&Kelso, Janet.(2018).Reconstructing the genetic history of late Neanderthals.NATURE,555(7698),652-+. |
| MLA | Hajdinjak, Mateja,et al."Reconstructing the genetic history of late Neanderthals".NATURE 555.7698(2018):652-+. |
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| hajdinjak2018.pdf（2909KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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